Ohio State built a comfortable lead and then gave up two touchdowns off turnovers late in the third quarter - and almost lost another fumble deep in its own territory on the next play - to slip past Michigan State in Columbus, Ohio.
The Buckeyes rolled for most of the first three quarters, building their big lead on two touchdown passes by Todd Boeckman, the running of Chris Wells and a bruising defense that thoroughly shut down Michigan State.
Ahead 24-0 late in the third quarter, they were seemingly in command and looking ahead to next week's test at Penn State.
In the span of four plays, it was 24-14 and Michigan State blew a chance to recover another Ohio State turnover on the very next play when two defenders touched Wells' fumble, but the back ended up recovering.
South Florida became the third second-ranked team to lose in the last three weeks, having their unexpected unbeaten run snapped by tricky Rutgers in Piscataway, N.J.
Third-string quarterback Andrew DePaola threw a 15-yard touchdown pass off a fake field goal to give the Scarlet Knights the lead in the third quarter and Rutgers also used a fake punt to set up a field goal in the first quarter.
BATON ROUGE, La. — Matt Flynn threw a 22-yard touchdown pass to Demetrius Byrd with a second left to lift fifth-ranked LSU to a 30-24 victory over No. 18 Auburn on Saturday night, keeping LSU's national title hopes alive.
With South Florida losing earlier in the week, LSU is certain to move up to at least third in the BCS standings, behind only Ohio State and possibly Boston College, which was idle this weekend.
Flynn finished with 319 yards passing and three touchdowns
Mackenzi Adams threw two touchdown passes and D.J. Moore had two key interceptions as Vanderbilt upset South Carolina in Columbia, S.C., ending Steve Spurrier's unblemished record against Vandy that began in 1987.
Spurrier came into this 14-0 all-time vs. the Commodores and, with the Gamecocks ranked as high as they'd been since 1984, seemed a strong bet to keep that streak alive.
Instead, Vanderbilt took a 17-0 lead in the first quarter and held off Spurrier's club the rest of the way.
Jonathan Stewart rushed for a career-high 251 yards and two touchdowns, and Andre Crenshaw added a pair of second-half scoring runs as Oregon held off pesky in Seattle.
With backfield-mate Jeremiah Johnson out of the season with a knee injury, the Ducks turned to Stewart as never before. The Seattle-area native who spurned Washington, responded with a career performance.
Stewart's 32 carries were seven more than his previous high. Stewart rushed for 144 yards at halftime, had 198 at the end of the three quarters, and became the first Oregon back to rush for 200 yards since Ontario Smith set a school record with 285 yards against Washington State in 2001.
Tim Tebow threw for a career-high four touchdowns and Florida rebounded from back-to-back losses with a victory over Kentucky in Lexington, Ky. It was the Gators' 21st straight win against the Wildcats.
The victory puts the defending national champions back in the Southeastern Conference title hunt despite their recent losses to Auburn and LSU. The Gators are now tied with South Carolina and Georgia for first in the SEC East.
Tebow connected on 18 of 26 passes for 256 yards. He nearly had a fifth TD pass, but Cornelius Ingram allowed the ball to slip through his fingers. Tebow's previous career-high of three TDs came earlier this year in games against Troy and Western Kentucky.
Mark Sanchez threw four touchdown passes in South Bend, Ind., - two on short drives after miscues by the Fighting Irish - and USC won by the largest margin of victory for the Trojans' in the 79-game history of the stories rivalry.
Sanchez threw TD passes of 10, 8, 5 and 48 yards and the Trojans won their sixth straight over the Irish, the longest streak for USC against Notre Dame. The Irish won 11 straight from 1983-93.
LaRod Stephens-Howling scored the go-ahead touchdown and was one of two Pittsburgh running backs with more than 100 yards of total offense, helping the Panthers upset Cincinnati in Pittsburgh.
Pitt, which had lost four in a row coming into the contest, didn't take the lead until Stephens-Howling carried the ball for the fifth consecutive play during a fourth-quarter drive that ended with a 7-yard score.
Cincinnati entered the game leading the Big East in rushing defense but was shredded by a Pitt running attack that featured big days by Stephens-Howling and LeSean McCoy. Stephens-Howling carried 13 times for 100 yards and McCoy, a freshman, gained 137 yards on 25 carries.
Jason Ricks kicked a 26-yard field goal with 2 seconds remaining and Oklahoma State overcame the best passing performance of Josh Freeman's career to beat Kansas State in Stillwater, Okla.
The Wildcats called all three of their timeouts as Ricks was setting up, but his kick was right down the middle to cap a comeback made necessary when K-State coach Ron Prince decided to go for two points instead of the tie after Leon Patton's 11-yard touchdown run with 1:10 remaining.
Josh Freeman threw for a career-best 404 yards and three touchdowns to star receiver Jordy Nelson, who also caught the go-ahead 2-point conversion, but it wasn't enough for the Wildcats.