Boston College (7-0) at Virginia Tech (6-1), 7:30 p.m., ESPN
The buzz: BC leads ACC in total offense (455.4 ypg). Hokies are last in the league in that category (298.9 ypg).
The line: Virginia Tech by 3.5. | The pick: Virginia Tech 20-17.
Air Force (6-2) at New Mexico (5-2), 9 p.m., Vs.
The buzz: Big game in Mountain West, as winner has inside track to finishing second.
The line: New Mexico by 6. | The pick: New Mexico 23-20.
Boise State (6-1) at Fresno State (5-2), 9 p.m., ESPN
The buzz: Big game in WAC, as winner remains in good shape to win league title.
The line: Boise State by 3. | The pick: Boise State 31-27.
Ball State (5-3) at Illinois (5-3), noon, Big Ten Network
The buzz: This is first of back-to-back Big Ten foes for Ball State, which is at Indiana next week.
The line: Illinois by 14. | The pick: Illinois 35-24.
Michigan State (5-3) at Iowa (3-5), noon, ESPN2
The buzz: Iowa has scored 23 total points the past three games. Michigan State gives up 25 points per game.
The line: Michigan State by 3. | The pick: Michigan State 23-17.
Pittsburgh (3-4) at Louisville (4-4), noon, Altitude/GamePlan
The buzz: From BCS hopeful to no bowl? After this, Louisville ends with West Virginia, USF and Rutgers.
The line: Louisville by 11. | The pick: Louisville 38-26.
Northwestern (5-3) at Purdue (6-2), noon, Big Ten Network
The buzz: Purdue has won eight of past 10 in series. But Northwestern has won two of past three.
The line: Purdue by 13. | The pick: Purdue 41-31.
West Virginia (6-1) at Rutgers (5-2), noon, ABC regional/GamePlan
The buzz: WVU is seventh in the BCS, and this is a must-win for Mountaineers to stay alive in title-game chase.
The line: West Virginia by 6.5. | The pick: WVU 34-28.
Colorado (4-4) at Texas Tech (6-2), noon, ABC regional/GamePlan
The buzz: Weird but true: At 540 air miles, Texas Tech is Colorado's closest "neighbor" in the Big 12.
The line: Texas Tech by 13.5. | The pick: Texas Tech 31-21.
North Carolina (2-5) at Wake Forest (5-2), noon, Lincoln Financial/GamePlan
The buzz: Wake CB Alphonso Smith has returned three picks for TDs this season.
The line: Wake Forest by 6. | The pick: Wake Forest 34-21.
Indiana (5-3) at Wisconsin (6-2), noon, Big Ten Network
The buzz: Family ties: IU co-defensive coordinator Joe Palcic's father, Bob, is Wisconsin's offensive line coach.
The line: Wisconsin by 7.5. | The pick: Wisconsin 38-28.
Mississippi State (4-4) at Kentucky (6-2), 12:30 p.m., Lincoln Financial/GamePlan
The buzz: UK has had an SEC-high 50 scoring drives this season. The average time of possession on those drives is 2:15.
The line: Kentucky by 13.5. | The pick: Kentucky 27-17.
Central Michigan (4-4) at Kent State (3-5), 1 p.m.
The buzz: Kent State starting QB Julian Edelman was lost for season with a broken arm last week.
The line: Central Michigan by 2.5. | The pick: Central Michigan 33-21.
Delaware (6-1) at Navy (4-3), 1 p.m., CSTV
The buzz: Blue Hens QB Joe Flacco, a Pitt transfer, will put pressure on Navy secondary; he's averaging 282.0 ypg passing.
The line: No line. | The pick: Navy 35-26.
Akron (3-4) at Buffalo (3-5), 1 p.m.
The buzz: Akron has won eight in a row over the Bulls.
The line: Buffalo by 1. | The pick: Akron 24-21.
Miami University (4-4) at Vanderbilt (4-3), 2 p.m.
The buzz: Vandy junior WR Earl Bennett is one catch away from tying SEC career receptions mark.
The line: Vandy by 14. | The pick: Vandy 27-14.
Florida International (0-7) at Arkansas (4-3), 2 p.m.
The buzz: We say McFadden and Jones each get 100 in the first half, then sit out the second half.
The line: Arkansas by 39. | The pick: Arkansas 56-13.
Iowa State (1-7) at Missouri (6-1), 2 p.m.
The buzz: Iowa State has scored 27 total points in its past three games. That's a good half for Mizzou.
The line: Missouri by 28.5. | The pick: Missouri 35-10.
UNLV (2-6) at Wyoming (4-3), 2 p.m., The mtn.
The buzz: Wyoming has allowed just one rushing TD this season, tied for fewest in nation with Ohio State.
The line: Wyoming by 11.5. | The pick: Wyoming 28-13.
USC (6-1) at Oregon (6-1), 3 p.m., Fox Sports Net
The buzz: Can Trojans' defense stop Ducks' powerful offense? And, more important, what uniforms will Oregon wear?
The line: Oregon by 3. | The pick: Oregon 28-24.
Memphis (3-4) at Tulane (2-5), 3 p.m.
The buzz: "He's No. 1! He's No. 1!" Tulane TB Matt Forte leads the nation in rushing (180.1 ypg).
The line: Tulane by 1.5. | The pick: Tulane 35-30.
SMU (1-6) at Tulsa (4-3), 3 p.m.
The buzz: Tulsa has scored 33 touchdowns this season. SMU has given up 34 touchdowns this season.
The line: Tulsa by 14. | The pick: Tulsa 48-28.
Arizona (2-6) at Washington (2-5), 3 p.m.
The buzz: Two teams in desperate search for a victory. They're a combined 1-10 since Sept. 8.
The line: Washington by 4. | The pick: Washington 24-17.
Louisiana Tech (2-5) at Utah State (0-7), 3 p.m., Altitude/GamePlan
The buzz: Let's hope the hounds can make it through the Wasatch Mountains. This is the dog of the week.
The line: Louisiana Tech by 2.5. | The pick: Louisiana Tech 30-21.
USF (6-1) at Connecticut (6-1), 3:30 p.m., ABC regional/GamePlan
The buzz: USF's impressive start basically will be forgotten if Bulls lose this to drop their second in a row.
The line: USF by 4.5. | The pick: USF 20-14.
UAB (2-5) at East Carolina (4-4), 3:30 p.m.
The buzz: This is first game in an easy closing stretch for ECU (Memphis, Marshall and Tulane follow).
The line: ECU by 13.5. | The pick: East Carolina 38-17.
Western Michigan (3-5) at Eastern Michigan (2-6), 3:30 p.m.
The buzz: Western's nation's-best streak of 33 consecutive games with a takeaway ended last week.
The line: Western Michigan by 5.5. | The pick: Western Michigan 34-20.
Georgia (5-2) at Florida (5-2), 3:30 p.m., CBS
The buzz: "World's Largest Outdoor Cocktail Party" has become "World's Most One-Sided Former Rivalry."
The line: Florida by 9. | The pick: Florida 24-17.
Clemson (5-2) at Maryland (4-3), 3:30 p.m., ABC regional/GamePlan
The buzz: This is Terps' fifth home game of season. The average score in first four: Terps 23, opponents 22.
The line: Clemson by 3.5. | The pick: Maryland 23-22.
Minnesota (1-7) at Michigan (6-2), 3:30 p.m., ESPN Classic
The buzz: This is for the "Little Brown Jug." Excuse Gophers fans if they want to fill it with booze and forget about this season.
The line: Michigan by 23.5. | The pick: Michigan 41-23.
Nebraska (4-4) at Texas (6-2), 3:30 p.m., ABC regional/GamePlan
The buzz: Huskers have allowed an average of 38 points per game in their past six. They're 2-4 in that span.
The line: Texas by 21. | The pick: Texas 41-17.
Baylor (3-5) at Kansas State (4-3), 3:30 p.m.
The buzz: Baylor has completed 210 passes this season. Big deal, right? Actually, it's just sixth time ever the Bears have completed 200 in a season.
The line: K-State by 25. | The pick: Kansas State 37-24.
La.-Monroe (2-5) at Florida Atlantic (4-3), 4 p.m.
The buzz: This is fourth meeting between these schools, and each of previous three was decided by seven or fewer points.
The line: FAU by 6.5. | The pick: FAU 35-20.
Idaho (1-7) at Nevada (3-4), 4 p.m., GamePlan
The buzz: Vandals have lost nine consecutive WAC games. This will be the 10th.
The line: Nevada by 16.5. | The pick: Nevada 42-19.
Rice (1-6) at Marshall (0-7), 4:30 p.m., CSTV
The buzz: Man, what a treat. It's not often you can watch a game involving teams that are a combined 1-13.
The line: Marshall by 8.5. | The pick: Marshall 31-27.
Virginia (7-1) at N.C. State (2-5), 4:30 p.m., ESPNU
The buzz: Virginia comes in on a seven-game winning streak. The Cavs never have won eight in a row.
The line: Virginia by 3. | The pick: Virginia 24-20.
Utah (5-3) at Colorado State (1-6), 5:30 p.m., The mtn.
The buzz: Utes TB Darrell Mack has turned in four consecutive 100-yard games and has five of them this season.
The line: Utah by 6. | The pick: Utah 31-20.
Ole Miss (2-6) at Auburn (5-3), 6 p.m., GamePlan
The buzz: "It's lonely at the bottom." Ole Miss is the only team in the SEC without a conference victory.
The line: Auburn by 17.5. | The pick: Auburn 35-14.
Ohio U. (3-5) at Bowling Green (4-3), 6 p.m., GamePlan
The buzz: Bowling Green has three players who have run for a TD, caught a TD pass and thrown a TD pass this season.
The line: Bowling Green by 7.5. | The pick: Bowling Green 30-17.
Stanford (3-4) at Oregon State (4-3), 6:30 p.m.
The buzz: Cardinal like it on the road - they've won seven of past nine away from home.
The line: Oregon State by 13.5. | The pick: Oregon State 28-16.
UCLA (5-2) at Washington State (2-5), 6:30 p.m., Fox Sports Net
The buzz: UCLA has won seven Pac-10 games in row and is tied for league lead with Arizona State.
The line: UCLA by 6. | The pick: UCLA 34-21.
Troy (5-2) at Arkansas State (3-4), 7 p.m., GamePlan
The buzz: Troy has had 18 receivers catch a pass this season, and 13 of them have a TD reception.
The line: Troy by 4.5. | The pick: Troy 34-28.
Middle Tennessee (3-5) at North Texas (1-6), 7 p.m.
The buzz: MTSU had nine sacks last week. And – uh oh – North Texas allowed nine sacks last week.
The line: MTSU by 13. | The pick: MTSU 40-14.
Kansas (7-0) at Texas A&M (6-2), 7 p.m., ESPN2
The buzz: A&M is No. 5 in nation in rush offense (260.1 ypg). KU is No. 7 nationally in rush defense (78.0 ypg).
The line: Kansas by 2.5. | The pick: Kansas 31-23.
Northern Illinois (1-7) at Toledo (3-5), 7 p.m.
The buzz: Toledo's Glass Bowl is a snake pit for visitors; the Rockets have won 41 of their past 47 at home.
The line: Toledo by 4. | The pick: Toledo 37-28.
NC Central (6-2) at Western Kentucky (4-3), 7 p.m.
The buzz: "Where are we?" This is first home game for Western Kentucky since Sept. 15.
The line: No line. | The pick: Western Kentucky 38-22.
South Carolina (6-2) at Tennessee (4-3), 7:45 p.m., ESPN
The buzz: Winner stays in hunt in SEC East. And to make things even more interesting, it's also Fulmer vs. Spurrier.
The line: Tennessee by 3. | The pick: South Carolina 17-13.
Duke (1-6) at Florida State (4-3), 8 p.m., ESPNU
The buzz: This is FSU's homecoming and fans should go home happy. The Seminoles never have lost (15-0) to Duke.
The line: Florida State by 17.5. | The pick: Florida State 26-14.
Ohio State (8-0) at Penn State (6-2), 8 p.m., ABC
The buzz: Nittany Lions' hopes for an upset depend on good run defense (OK) and a steady game from Anthony Morelli (yikes).
The line: Ohio State by 4. | The pick: Ohio State 20-14.
Houston (4-3) at UTEP (4-3), 9 p.m.
The buzz: These teams average a combined 966.1 yards of offense per game. And they give up a combined 845.0 yards per game.
The line: Houston by 3.5. | The pick: Houston 49-42.
California (5-2) at Arizona State (7-0), 10 p.m., Fox Sports Net
The buzz: These are the two best teams in the Pac-10 at forcing turnovers. Cal has forced 18, Arizona State 17.
The line: Arizona State by 3. | The pick: Arizona State 33-31.
New Mexico State (4-4) at Hawaii (7-0), midnight
The buzz: We expect the teams to combine to throw at least 110 passes. The Division I-A single-game record is 135.
The line: Hawaii by 28. | The pick: Hawaii 56-31.
UCF (4-3) at Southern Miss (4-3), 8 p.m., ESPN
The buzz: This essentially is a loser-leaves-the-race game in Conference USA's East Division.
The line: Southern Miss by 2.5. | The pick: Southern Miss 28-24.
38-18 straight up, 23-26-3 against the spread.
369-112 straight up, 201-197-8 against the spread. (Games involving I-AA teams don't have point spreads.)
Mike Huguenin is the college sports editor for Rivals.com. He can be reached at firstname.lastname@example.org.