Matt Flynn passed for 237 and three touchdown and led LSU to a comfortable win over Louisiana Tech in Baton Rouge, La.
In 17 previous meetings between LSU and Louisiana Tech spanning more than a century, the Bulldogs had beaten LSU only once, and that was back in 1904. LSU was favored to win this one by about five touchdowns, a margin they held midway through the third quarter.
Flynn's scoring strikes included a career-long 71-yarder to Terrance Toliver, which was also a career long reception for the freshman receiver.
DeMarco Murray scored four touchdowns, one on a 91-yard kickoff return, as Oklahoma beat Baylor in Norman, Okla.
Oklahoma has not lost to Baylor in 17 meetings between the teams. Baylor lost its seventh straight game amid reports that its coach, Guy Morriss, would be replaced at the end of the season.
Murray, who had 13 rushes for 95 yards, is the first Oklahoma freshman to score at least three touchdowns in one game on three separate occasions. He has 15 touchdowns this season, tying the school record for freshmen set by Adrian Peterson.
Marcus Henry had a career-high 199 yards receiving and three touchdowns, Brandon McAnderson ran for 142 yards and two scores, and the Jayhawks stayed unbeaten with a victory over Oklahoma State in Stillwater, Okla.
Kansas moved to 10-0 for the first time since it finished the 1899 season with that record, and is now the only unbeaten team left in the six conferences with an automatic bid to the BCS.
Pat White scored on a 50-yard run with 1:36 remaining to lift West Virginia over Louisville on Thursday night in Morgantown, W.Va.
Brian Brohm brought Louisville from 17 points down in the second half, with the Cardinals tying it on Art Carmody's 37-yard field goal with 3:05 left. White, who had threw TD passes, then capped a 65-yard drive with his scoring run up the left sideline.
Brohm, who broke his own Big East record with his seventh 300-yard game of the season, threw a desperation pass that Antonio Lewis intercepted at the West Virginia 7.
The win allowed West Virginia to remain on Connecticut's heels for a berth in a BCS bowl.
Jeremy Maclin caught two touchdown passes, one to pull Missouri out of late trouble and the other on the school's longest reception in 31 years, in a victory over Texas A&M in Columbia, Mo.
Chase Daniel threw three touchdown passes for Missouri (9-1, 5-1 Big 12), which reached nine victories for the first time since 1969 and only the fourth time in school history. The Tigers scored nine points in the final 3:44 on Maclin's 12-yard grab and a safety when Lorenzo Williams sacked Stephen McGee in the end zone to avert a second-half collapse.
Missouri set a single-season scoring record of 411 points, 12 more than the 2003 team in a 13-game season, with at least three games to go.
They also finished 5-0 at Faurot Field and clinched their first winning record in conference play under coach Gary Pinkel, in his seventh season.
Playing against a struggling team mired in a three-game losing streak, Boston College yielded 472 yards and five touchdowns in a loss in College Park, Md.
Matt Ryan, who threw three interceptions against Florida State, went 33-for-56 for 421 yards and three touchdowns, but was intercepted twice.
The injury-plagued Terrapins played with a makeshift offensive line and without leading rusher Keon Lattimore (hamstring). Maryland was also without second-leading receiver Danny Oquendo (knee), and standout linebacker Erin Henderson played despite sitting out practice all week with a sore back.
Keegan Herring rushed for 116 yards, including a 71-yard touchdown, and Rudy Carpenter threw for 200 yards and another score to lead Arizona State to a victory over UCLA in Pasadena, Calif.
Herring's running and Carpenter's passing gave Arizona State just enough to overcome the Bruins, who kept the game close despite using their fourth quarterback of the year and starting their third-string running back.
Matthew Stafford threw a pair of touchdown passes and Knowshon Moreno broke 100 yards rushing for the fourth straight game, leading Georgia past Auburn in Athens, Ga.
The Bulldogs remained on top of the Southeastern Conference East with a 5-2 mark, but they'll need a little help to reach the Dec. 1 championship game in nearby Atlanta. Tennessee has only two SEC losses, too, and holds the tiebreaker over Georgia.
Whatever the outcome in the league race, the Bulldogs will long savor this win over their longest-running rival. In the 111th meeting between the schools, Stafford threw a 58-yard TD pass to Mohamed Massaquoi and a 13-yarder to Sean Bailey. Moreno, a redshirt freshman, had another big game with scoring runs of 24 and 2 yards, finishing with 101 yards on 22 carries.
Tyrod Taylor and Virginia Tech didn't make coach Frank Beamer suffer through another disheartening loss to Florida State, but the Hokies sure made their coach and fans sweat it out until late in Blacksburg, Va.
Taylor returned from a sprained ankle that kept him out 2 1/2 games and threw for two touchdowns and ran for another. It was the first win for Beamer in eight tries against Florida State, and marked the first time Seminoles coach Bobby Bowden has lost to Virginia Tech in 16 career meetings.
The Hokies blew a 14-point halftime lead and trailed 21-20 entering the final quarter, but Taylor drove them to his go-ahead 3-yard scoring run, and three late Seminoles turnovers made a close game turned lopsided.
Chauncey Washington ran for a career-high 220 yards and a touchdown, and USC beat California in a rain-soaked matchup that was much more tantalizing before both schools blew their national title hopes last month.
John David Booty passed for 129 yards and a score for the Trojans, who stayed in the conference and BCS races by faring slightly better in the steady precipitation that drenched Strawberry Canyon in Berkeley, Calif., all night, causing both teams to flounder with footing, execution and tackling.
Colt Brennan tied the NCAA career mark for touchdown passes, throwing his 121st before he was knocked out of the game, as Hawaii remained undefeated by holding off Fresno State in Honolulu.
Brennan was 28-of-39 for 396 yards and two touchdowns before he left in the fourth quarter. The Warriors are off to their best start since 1925 and kept their BCS hopes alive. They have won 10 straight, and 19 of their last 20 games.
Brennan's 5-yard TD toss to Davone Bess gave Hawaii a 31-7 lead and matched the mark set by Brigham Young's Ty Detmer in 1991. With the score, Brennan also tied Detmer's record for most touchdowns responsible for with 135.
Ben Mauk threw for three touchdowns and ran for another, leading Cincinnati to a victory over Connecticut in Cincinnati that further scrambled the conference race.
Under heavy pressure throughout the game, Mauk made the two decisive plays in the second half. He ran 11 yards for a touchdown on a draw play, then connected with Dominick Goodman on a 37-yard touchdown pass, keeping Cincinnati in a crowd of teams vying for the league title.
Tim Tebow accounted for all seven of Florida's touchdowns, a school record five rushing and two passing, as the Gators kept alive their hopes of making the SEC title game with a victory over South Carolina in Columbia, S.C.
Tebow was 22-for-32 for a career-best 304 yards and ran for 120 yards, accounting for more than three-quarters of the offense for the No. 17 Gators.
With Florida's dual-threat receiver Percy Harvin out with sinus problems, Tebow took over, running things so efficiently the Gators didn't have a play lose yards until things were well in hand midway through the third quarter.
Taylor Tharp completed 26 of 29 passes for 283 yards and two touchdowns in just three quarters as No. 19 Boise State beat Utah State in Logan, Utah.
The Broncos won their eighth straight and did nothing to hurt themselves in the next rankings as they try to make a late run in the BCS standings and crack the Bowl Championship Series for a second straight year.
Boise State overwhelmed the hapless Aggies, who have lost 16 in a row and were down by two touchdowns barely six minutes into the game.
Anthony Johnson returned an interception a school-record 100 yards for a touchdown and Mississippi State became bowl eligible Saturday for the first time since 2000 with an upset of Alabama in Starkville, Miss.
It was the second straight win over his alma mater for Sylvester Croom, whose resurgent Bulldogs have won six games for the first time since 2000.
It also was the second straight win over a ranked opponent for Mississippi State, which beat then-No. 14 Kentucky two weeks ago. The win gave the Bulldogs a 2-2 record during a streak of four consecutive games against ranked opponents.
Erik Ainge threw for two touchdowns and Arian Foster ran for another as Tennessee beat Arkansas in Knoxville, Tenn.
The Volunteers kept their drive for an SEC Eastern Division title alive and again silenced critics of coach Phillip Fulmer with a balanced offensive attack and one of their best defensive performances of the season.
Arkansas' Darren McFadden, the SEC's top rusher, finished with 117 yards on 22 carries and threw for a touchdown, and Casey Dick completed 12 of 22 for 140 yards and two interceptions.
Virginia ended Miami's 70-year stay at Miami's Orange Bowl in stunningly one-sided fashion, dealing the Hurricanes the biggest shutout loss in the stadium's history. Mikell Simpson had a pair of 1-yard touchdown runs and quarterback Jameel Sewell scored twice, as the Cavaliers simply overpowered Miami.
Chris Cook had a 44-yard fumble return for a score with 2:26 left, putting Virginia's effort into the Miami history books. It topped the 44-0 beating Notre Dame put on the Hurricanes at the Orange Bowl in 1973.
So how's this for one last piece of Orange Bowl history? It was Miami's first home shutout loss since Oct. 4, 1974 against Auburn, and the Hurricanes' worst defeat since losing 66-13 at Syracuse on Nov. 28, 1998. The last time Miami lost this badly at home was in 1944, when Texas A&M beat the Hurricanes 70-14.
Andre' Woodson threw for 222 yards, Rafael Little had 70 yards rushing and Kentucky beat Vanderbilt in Nashville, Tenn., to keep its slim hopes of a birth in the Southeastern Conference title game alive.
The Wildcats snapped their two-game losing skid and clinched consecutive seven-win seasons for the first time since 1976-77. Kentucky still plays SEC East rivals Tennessee and Georgia, and has a chance to sneak into the league title game in Atlanta by defeating both.